QB/T 2335-2012 English PDF (QBT2335-2012)

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QB/T 2335-2012: Oral care and cleansing products. Sorbitol solution for toothpaste
QB/T 2335-2012
LIGHT INDUSTRY STANDARD OF
THE PEOPLE’S REPUBLIC OF CHINA
ICS 71.100.40
Classification number: Y43
Registration number: 36653-2012
Replacing QB/T 2335-2007
Oral care and cleaning products -
Sorbitol solution for toothpaste
ISSUED ON: MAY 24, 2012
IMPLEMENTED ON: NOVEMBER 01, 2012
Issued by: Ministry of Industry and Information Technology of PRC
Table of Contents
Foreword ... 3 
1 Scope ... 4 
2 Normative references ... 4 
3 Classification of products ... 5 
4 Requirements ... 5 
5 Test methods ... 7 
6 Inspection rules ... 18 
7 Marking, packaging, transportation, storage, shelf life ... 20 
Appendix A (Normative) Conversion of sorbitol sugar Brix (BX) and solids (DS)
... 22 
Foreword
The degree of conformity between this standard and the United States
Pharmacopoeia (USP) is non-equivalent.
This standard is a revision of the standard QB/T 2335-2007 “Sorbitol solution
for toothpaste”.
As compared with the QB/T 2335-2007, the main changes of this standard are
as follows:
- DELETE the moisture indicators and the experimental methods;
- DELETE the refractive index and the experimental method;
- DELETE the unit of relative density indicator;
- REVISE the requirements for shelf life.
This standard was proposed by the China Light Industry Association.
This standard shall be under the jurisdiction of the National Toothpaste
Waxwork Standardization Center.
Responsible drafting organizations of this standard: Beijing Baojie Technology
Co., Ltd., Shandong Tianli Pharmaceutical Co., Ltd., National Light Industry
Toothpaste Waxwork Products Quality Supervision and Testing Center.
The main drafters of this standard: Wang Yun, Li Xianbo, Zou Bin, Wang Xinjian,
Yan Qingsong, Meng Yu.
This standard was first published on December 4, 1997. This is the second
revision.
This standard, from the date of implementation, replaces the light industry
standard QB/T 2335-2007 “Sorbitol solution for toothpaste” issued by the
former Light Industry Association.
Oral care and cleaning products -
Sorbitol solution for toothpaste
1 Scope
This standard specifies the product classification, requirements, test methods,
inspection rules, marking, packaging, transportation, storage, shelf life of
sorbitol solution for toothpaste.
This standard is applicable to sorbitol solution which is obtained by
hydrogenation reaction and refining under the action of a catalyst using liquid
glucose as a raw material. This product is used as a humectant in the
toothpaste industry.
2 Normative references
The following documents are essential to the application of this document. For
the dated documents, only the versions with the dates indicated are applicable
to this document; for the undated documents, only the latest version (including
all the amendments) are applicable to this standard.
GB 7658-2005 Food additive - Sorbitol solution
GB/T 601 Chemical reagent - Preparations of standard volumetric solutions
GB/T 602 Chemical reagent - Preparations of standard solutions for impurity
GB/T 603 Chemical reagent - Preparations of reagent solution for use in test
GB/T 6283 Chemical products - Determination of water Karl·fischer method
(general method)
GB/T 6678 General principles for sampling chemical products
GB/T 6680 General rules for sampling liquid chemical products
GB/T 6682 Water for analytical laboratory use - Specification and test
methods
GB/T 8170 Rules of rounding off for numerical values
JJF 1070-2005 Rules of metrological testing for net quantity of products in
5 Test methods
The original sample is thoroughly mixed and used as a test sample (abbreviated
as specimen).
The reagents and water used in this standard are analytically pure reagents
and grade-3 water which comply with GB/T 6682 unless otherwise specified.
In the standard, the standard solution for titration analysis, the standard solution
for impurity determination, the preparations and products used in the test
method are prepared according to the provisions of GB/T 601, GB/T 602, GB/T
603, unless otherwise specified.
5.1 Determination of sensory index
5.1.1 Appearance
Take specimen. Put it into a colorimetric tube. Make visual observation.
5.1.2 Smell
Take specimen. Put it in a bottle with cover. Open the cover. Sniff it.
5.1.3 Taste
Take specimen. Taste it.
5.2 Determination of color
5.2.1 Materials
Nessler colorimetric tube: 50 mL.
5.2.2 Reagents
5.2.2.1 Ferric chloride.
5.2.2.2 Cobalt dichloride.
5.2.2.3 Dilute hydrochloric acid: 1 + 40.
5.2.3 Standard colorimetric stock solution
Solution A: Weigh 22.5 g of ferric chloride (accurate to 0.001 g). Dissolve it in
dilute hydrochloric acid solution, to make the total volume of the solution reach
500 mL. 1 mL of this solution contains 45 mg of ferric chloride.
Solution B: Weigh 5.95 g of cobalt dichloride (according to 0.001 g). Dissolve it
content of the specimen.
The solid content is expressed as mass fraction X2 and is calculated according
to formula (1):
Where:
X2 - Solid content, %;
X1 - Moisture of specimen, %.
5.4.3 Method 2
Operating procedure: First use the Abbe refractometer to determine the sugar
Brix BX at (20 ± 1) °C. Then check the solids of sorbitol of the corresponding
specifications in Appendix A, to obtain the solid content of the specimen.
5.5 Determination of sorbitol content
5.5.1 Determination of sorbitol content by normalization method
5.5.1.1 Summary of method
Use the liquid chromatography, under the selected working conditions, use
water as the mobile phase, the various components in the specimen with
different adsorption coefficients are successively separated by the packing in
the column. Use the differential refraction detector for testing. Use the
normalized method to quantitatively calculate the mass fraction of the sorbitol
component.
5.5.1.2 Reagents
Pure water: Conductivity is less than 3 μS/cm. It is filtered through a 0.45 μm
membrane filter paper and heated or ultrasonically degassed.
5.5.1.3 Instruments
High-performance liquid chromatography (HPLC), including the following
components:
- High-pressure pump: No pulse, which can keep the flow rate at 0.1 mL/min
~ 10.0 mL/min;
- Column: See Table 3;
- Differential refraction detector;
Au - The peak area of the sorbitol component in the specimen solution;
As - The total peak area of all components in the specimen solution.
5.5.1.6 Representation of results
Use the mass fraction to represent the sorbitol content X3, which is calculated
according to formula (3).
Where:
w100 - The mass fraction of sorbitol in 100 g of dry matter, %;
X2 - Solid content of specimen, %.
Note: The chromatographic workstation may use the above formula in the
computer software programming for automatic calculation.
Take the arithmetic mean of the results of two parallel determinations as the
determination result. The absolute difference between the results of the two
parallel determinations is not more than 0.5%.
5.5.2 Determination of sorbitol content by external standard method
(arbitration method)
It is determined according to the method of 4.5 in GB 7658-2005.
5.6 Determination of relative density
5.6.1 Instruments
5.6.1.1 Density bottle equipped with thermometer: The volume is 25 mL.
5.6.1.2 Analytical balance: The sensitivity is 0.0001 g.
5.6.1.3 Constant-temperature w...